Wellbutrin, known for its generic name bupropion, is an antidepressant with several on and off-label uses. It is FDA-approved for the treatment of depression, specifically, major depressive disorder (MDD). It is, as a matter of fact, the go-to for the treatment of depression. It is also approved for the treatment of seasonal affective disorder (SAD) in addition to being indicated as an effective smoking cessation aid.